Hi jimbo and welcome to the forums.
First up is budget and what type of club you are looking for. Older club, dance club, rave, teen club, etc etc. Each type will have a different atmosphere and thus use different fixtures and different types of lighting. For example, in high energy dance and rave clubs, you are going to want strobes and haze most likely. For older type clubs, strobes probably won't go over too well.
That is a large area to cover for sure. If you are planning on hanging lights all the way up at the 50' mark, you are going to need some powerful lights (575w movers and/or beams, high wattage LED fixtures, etc). If you can mount lower, you will be able to use much less powerful fixtures.
Any idea, why not mount a truss system in the room? You can get the lights lower and give the people something to look at vs lights all the way up in the rafters. Again, not sure what type of look or club you are going for, but it can be done in many ways on different budget levels. If you do go that route, make sure you have someone with experience hang and install any truss system. It is something that is very dangerous and can be a huge liability if done wrong.
(Side note for Jim, sorry I have been MIA. Working a Lincoln Financial meeting right now, don't worry, have some pictures. Also just finished one of the best designs of my life last week for a dance show. Can't wait to show you the video on that one
. I will watch the video when I come up for air. Back to my corporate hole
)